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pentobarbital will minimize the extent or outcome of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Pitolisant publicity is decreased by fifty% if coadministered with strong CYP3A4 inducers.pentobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use